I don't bring this up to get anyone down, or convince you to stop sending your resume out. On the contrary, this is a reminder that competition for jobs is stiff and, therefore, you shouldn't get frustrated or disgruntled if you haven't gotten a response after applying to dozens (or more) job openings.
What I do recommend, if you're looking for a job, is to think of other ways to be proactive in your search, in addition to the traditional method. This is where networking comes into play. If you're a recent grad, try to work some of your college connections. If you're have more experience under your belt, start talking to former colleagues and try to make new connections at industry events. And, remember, it often takes a minimum of six months to find a first (or new) job. With a recession on the horizon, maybe longer.